In this post… The Brenner hypothesis Tubuloglomerular feedback & glomerulotubular balance How SGLT2i affect glomerular haemodynamics How loop diretics effect glomerular haemodynamics The importance of intraglomerular pressure At the cornerstone of contemporary treatments to delay CKD progression are agents (RAS inhibitors and SGLT2i) that reduce intraglomerular pressure. Whether or not this effect is the most important mechanism of nephroprotection is open to debate - particularly for SGLT2i. However, it is at the very least likely to be a central mechanism.