In this post… What effect do loop diuretics have on renal free water clearance? Should we stop furosemide in hyponatraemia? Why do we need to restrict water intake when giving furosemide in hyponatraemia? We are mostly water and rapidly run into trouble when we become under- or over-hydrated. We could argue, therefore, that one of the kidney’s most important jobs is that of maintaining water homeostasis. It is surprising that we are able to mess around quite profoundly with this process without running into trouble more frequently than we do.

In this post… Electrolyte-free water clearance can help assess disorders of sodium homeostasis Potassium supplementation can help in cases of hyponatraemia What are we made of? What are little girls made of? What are little girls made of? Sugar and spice And all things nice That’s what little girls are made of — Nursery Rhyme Well we are not made of sugar and spice - but what are we made of?

In this post… How the kidney evolved to filter first and reabsorb later How we came to know how the kidney works in this way It is so obvious! ‘One never notices what has been done; one can only see what remains to be done.’ — Marie Curie As facts become established dogma, it becomes almost impossible to conceive of a time when they were not known. How could we have not known about natural selection before Darwin?